Katalase

CAT
Tilgængelige strukturer PDB Ortologsøgning: PDBe RCSB Liste over PDB-idkoder 1DGB, 1DGF, 1DGG, 1DGH, 1F4J, 1QQW
Identifikatorer
Aliaser	CAT, catalase
External IDs	OMIM: 115500 MGI: 88271 HomoloGene: 55514 GeneCards: CAT
Genontologi Molekylær funktion • protein homodimerization activity • aminoacylase activity • peroxidase activity • metal-ion-binding • oxidoreductase activity, acting on peroxide as acceptor • catalase activity • antioxidant activity • hæm binding • NADP binding • enzyme binding • oxidoreductase activity • receptor-binding • identical protein binding Cellulær komponent • cytosol • Golgiapparat • membran • intracellular membrane-bounded organelle • focal adhesion • mitochondrial intermembrane space • peroxisomal membrane • Peroxisom • cellemembran • peroxisomal matrix • Endoplasmatisk reticulum • Mitokondrie • Lysosom • Ekstracellulært exosom • ekstracellulære region • ekstracellulære rum • secretory granule lumen • ficolin-1-rich granule lumen Biologisk proces • response to phenylpropanoid • ureteric bud development • response to estradiol • respons på hypoxi • response to cadmium ion • response to fatty acid • kidney development • response to inactivity • response to hyperoxia • cellular response to growth factor stimulus • aldring • cholesterol metabolic process • response to L-ascorbic acid • negative regulation of apoptotic process • response to ozone • response to oxidative stress • response to activity • protein tetramerization • response to vitamin E • response to insulin • response to vitamin A • aerobic respiration • response to lead ion • positive regulation of NF-kappaB transcription factor activity • osteoblast differentiation • hydrogen peroxide catabolic process • UV protection • positive regulation of phosphatidylinositol 3-kinase signaling • response to radiation • response to light intensity • response to ethanol • negative regulation of NF-kappaB transcription factor activity • oxidation-reduction process • triglyceride metabolic process • protein homotetramerization • response to UV • response to toxic substance • respons på hydrogenperoxid • response to drug • hemoglobin metabolic process • positive regulation of cell division • cellular oxidant detoxification • neutrophil degranulation • response to reactive oxygen species • cellular response to oxidative stress • protein targeting to peroxisome Sources:Amigo / QuickGO
RNA-udtryksmønster
Flere henvisninger til udtrykdata
Ortologer
Art	Menneske	Mus
Entrez	847	12359
Ensembl	ENSG00000121691	ENSMUSG00000027187
UniProt	P04040	P24270
RefSeq (mRNA)	NM_001752	NM_009804
RefSeq (protein)	NP_001743	NP_033934
Location (UCSC)	n/a	Chr 2: 103.45 – 103.49 Mb
PubMed-søgning
Wikidata
Vis/Rediger Menneske Vis/Rediger Mus

Katalase (EC 1.11.1.6) er et enzym fundet i næsten alle levende organismer. Dets funktioner inkluderer katalyse af nedbrydelsen af brintoverilte til vand og ilt. Katalase har en af de højeste turnover-hastigheder af alle enzymer; et molekyle katalase kan omdanne cirka 40 millioner af molekyler brintoverilte til vand og ilt per sekund.

Katalase er en tetramer af fire polypeptidkæder, som hver er over 500 aminosyrer lange. Det indeholder fire porfyrin hæm-grupper, der tillader enzymet at reagere med brintoverilte. pH-optimum for katalase ligger omkring 7, mens temperaturoptimum varierer fra art til art, afhængig af polypeptidkædernes sammensætning.