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Tauopati

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Tauopati
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Diagram af normal mikrotubuli og en påvirket af tauopati.

Tauopati tilhører en klasse af neurodegenerative sygdomme associeret med den patologiske aggregering af tau-protein i neurofibrillære elle gliofibrillære knuder[1] i den menneskelige hjerne. Knuderne dannes af hyperfosforylering af et mikrotubuli-associeret protein kendt som tau, hvilket får det til at aggregerer i en uopløselig form. (Disse aggregationer af hyperfosforyleret tau-protein kaldes også paired heliske filamenter). Den præcise mekanisme hvorved knuderne formes kendes ikke præcist, og det er stadig kontroversielt om knuderne er primære kausale faktor i sygdommen eller spiller en mere perifer rolle. Primære tauopatier, altså lidelser hvor neurofibrillære knuder (NFT) primært observeres, inkluderer:

[3][4]

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