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CDKN2A Identifikatorer Aliaser CDKN2A External IDs OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A Genetisk-relaterede sygdomme melanoma-pancreatic cancer syndrome , mucosal melanoma , modermærkekræft , familial atypical multiple mole melanoma syndrome [ 1] Genontologi Molekylær funktion • NF-kappaB binding • GO:0001948, GO:0016582 proteinbinding • cyclin-dependent protein serine/threonine kinase inhibitor activity • protein kinase binding • RNA binding • DNA binding • p53 binding • transcription factor binding • MDM2/MDM4 family protein binding • ubiquitin-protein transferase inhibitor activity • SUMO transferase activity • disordered domain specific binding • GO:0090645, GO:0061637 ubiquitin ligase inhibitor activity Cellulær komponent • cytoplasma • cytosol • senescence-associated heterochromatin focus • Cellekerne • nuclear body • nucleoplasm • Kernelegeme • Mitokondrie • GO:0009327 protein-containing complex Biologisk proces • positive regulation of smooth muscle cell apoptotic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • replicative senescence • G1 phase • negative regulation of cell-matrix adhesion • cellular senescence • negative regulation of cell growth • positive regulation of cellular senescence • positive regulation of macrophage apoptotic process • cell cycle • Ras protein signal transduction • negative regulation of phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • negative regulation of cell population proliferation • G1/S transition of mitotic cell cycle • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • GO:0097285 Apoptose • regulation of G2/M transition of mitotic cell cycle • GO:0009373 regulation of transcription, DNA-templated • regulation of protein stability • negative regulation of immature T cell proliferation in thymus • regulation of protein export from nucleus • negative regulation of protein kinase activity • negative regulation of proteolysis involved in cellular protein catabolic process • protein K63-linked ubiquitination • positive regulation of signal transduction by p53 class mediator • somatic stem cell division • protein stabilization • protein polyubiquitination • positive regulation of protein sumoylation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • autophagy of mitochondrion • apoptotic mitochondrial changes • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of ubiquitin-protein transferase activity • positive regulation of apoptotic process • rRNA processing • negative regulation of ubiquitin-dependent protein catabolic process • mitochondrial depolarization • positive regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of B cell proliferation • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of apoptotic DNA fragmentation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of protein localization to nucleus • protein sumoylation • GO:1901313 positive regulation of gene expression • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity • amyloid fibril formation • negative regulation of protein neddylation Sources:Amigo / QuickGO
RNA-udtryksmønster Flere henvisninger til udtrykdata Ortologer Art Menneske Mus Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) n/a Chr 4: 89.19 – 89.21 Mb PubMed -søgning[ 2] [ 3] Wikidata
CDKN2A, også kendt som cyclin-dependent kinase Inhibitor 2A, er et gen , der i mennesker er placeret i kromosom 9 , bånd p21.3.[ 4] [ 5] proteiner , heriblandt p16 (eller p16INK4a) og p14arf .[ 6] tumorsuppressorer ved at regulere cellecyklussen .
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