Solidarity Trial
Solidarity Trial er et multinationalt klinisk fase III-IV-forsøg organiseret af Verdenssundhedsorganisationen WHO og partnere der skal sammenligne behandlinger og vacciner for patienter med sygdommen COVID-19 forårsaget af SARS-CoV-2 under Coronaviruspandemien i 2019-2020. De blev annonceret den 18. marts 2020.[1]
Forsøgene for behandlinger kaldes Solidarity Therapeutics Trial ('Solidarity clinical trial for COVID-19 treatments').[2] En opdatering med midlertidige resultater (interim results) fra WHO 15. oktober 2020 "... appeared to have little or no effect ..." [note 1]
Forsøgene for vacciner kaldes Solidarity Vaccine Trial ('Solidarity trial for coronavirus vaccines').[3] Maj 2020 annoncerede WHO en international koalition til samtidig udvikling af flere kandidatvacciner til forebyggelse af COVID-19.[4] I Danmark begyndte man 27. december 2020 vaccination med vaccine fra en af disse kandidater.[5]
Noter og referencer[redigér | rediger kildetekst]
- Noter
- ^ Updatering med midlertidige resultater (interim results) fra WHO 15. oktober 2020: "Solidarity Therapeutics Trial produces conclusive evidence on the effectiveness of repurposed drugs for COVID-19 in record time" fra Who.int ("... Interim results from the Solidarity Therapeutics Trial, coordinated by the World Health Organization, indicate that remdesivir, hydroxychloroquine, lopinavir/ritonavir and interferon regimens appeared to have little or no effect on 28-day mortality or the in-hospital course of COVID-19 among hospitalized patients. ..." − Dansk omtrent: Midlertidige resultater fra Solidarity Therapeutics Trial, koordineret af Verdenssundhedsorganisationen, indikerer at regimerne for remdesivir, hydroxychloroquin, lopinavir/ritonavir og interferon viste sig at have ringe eller ingen effekt på dødeligheden efter 28 dage eller for forløbet af COVID-19 for indlagte patienter på hospitler)
- Referencer
- ^ "UN health chief announces global 'solidarity trial' to jumpstart search for COVID-19 treatment" (engelsk). United Nations, World Health Organization. 18. marts 2020. Hentet 2. april 2020.
- ^ "'Solidarity' clinical trial for COVID-19 treatment". www.who.int (engelsk). World Health Organization. Hentet 2020-04-22.
{{cite web}}: CS1-vedligeholdelse: url-status (link) - ^ 'An international randomised trial of candidate vaccines against COVID-19' fra Who.int, 9. april 2020. 'Outline of solidarity vaccine trial', '.. a draft. The content of this document is not final ...' − WHO R&D Blueprint novel Coronavirus (R&D: Research and Development)
- ^ "Update on WHO Solidarity Trial – Accelerating a safe and effective COVID-19 vaccine". World Health Organization. 2020-04-27. Hentet 2020-05-02.
It is vital that we evaluate as many vaccines as possible as we cannot predict how many will turn out to be viable. To increase the chances of success (given the high level of attrition during vaccine development), we must test all candidate vaccines until they fail. WHO is working to ensure that all of them have the chance of being tested at the initial stage of development. The results for the efficacy of each vaccine are expected within three to six months and this evidence, combined with data on safety, will inform decisions about whether it can be used on a wider scale
− Dansk omtrent: "Det er vigtigt, at vi evaluerer så mange vacciner som muligt, da vi ikke kan forudsige, hvor mange der vil vise sig at være levedygtige. For at øge chancerne for succes (i betragtning af det høje niveau af nedslidning (attrition) under vaccineudviklingen) skal vi teste alle kandidatvacciner indtil de fejler. WHO arbejder for at sikre, at de alle har chancen for at blive testet i den indledende udviklingsfase. Resultaterne for effektiviteten af hver vaccine forventes inden for tre til seks måneder, og dette bevis kombineret med data om sikkerhed, vil informere beslutninger om, hvorvidt det kan bruges i større skala" - ^ "Så er vi i gang - i dag bliver de første vaccineret mod COVID-19" fra Sst.dk, Sundhedsstyrelsen, 27. december 2020
Se også[redigér | rediger kildetekst]
- Afsnittet 'Vaccine' i artiklen om coronaviruspandemien
Eksterne henvisninger[redigér | rediger kildetekst]
- (Behandlinger) "Repurposed antiviral drugs for COVID-19 – interim WHO SOLIDARITY trial results" fra medRxiv, Medrxiv.org, 15. oktober 2020 (en) − "med-archive" : a preprint server for health issues, (for the distribution of preprints that are complete but unpublished manuscripts describing health research.)
- (Vacciner) ‘Solidarity’ trial for vaccines vs COVID-19 to start in December fra Business World, Bworldonline.com, 26. oktober 2020
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